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KMID : 0391520110190010054
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Journal of the Korean Child Neurology Society
2011 Volume.19 No. 1 p.54 ~ p.60
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Neurologic Complications of Novel Influenza A (H1N1) Virus Infection from 2009-2011.
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Kim Ran-Hee
Kim Young-Mi
Park Su-Eun
Kim Hye-Young
Lee Yoon-Jin
Kim Tae-Hyoung
Nam Sang-Ook
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Abstract
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Purpose: To describe the characteristics and incidence of neurologic complications related to the novel influenza A (H1N1) virus.
Methods: We reviewed the medical records of 752 children and adolescence (< or = 18 years of age) who had been diagnosed as novel influenza A (H1N1) infection through positive results of influenza A (H1N1) RT-PCR and hospitalized or visited the outpatient clinic and emergency department of Pusan National University Hospital from July 2009 to January 2011.
Results: We identified 15 patients who had experienced a neurologic symptom with a mean age of 8.8 years. There were 10 (66.7%) males and five (33.3%) females. Nine patients (60.0%) presented with seizures, two (13.3%) with decreased mentality, two (13.3%) with visual hallucination, and one (6.7%) with vertigo. The mean duration from onset of respiratory illness to the beginning of neurologic symptoms was 2 days (range: 0-4 days). Three patients (patient 2, 7, and 13) (20.0%) had abnormal results on cerebrospinal fluid analysis; however, novel influenza A (H1N1) was not detected. Further, one patient (6.7%) had abnormal MRI. Antiviral therapy (oseltamivir) was administered to fourteen patients (93%) and all patients recovered fully and had no neurologic sequelae.
Conclusion: Novel influenza A (H1N1) was a cause of neurologic symptoms during the outbreak. Pediatricians should consider influenza virus infection in the differential diagnosis for children with neurologic symptoms during an epidemic of influenza.
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KEYWORD
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Influenza A, H1N1 subtype, Neurologic manifestations
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